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NAC in very high doses (above 1800mg daily) can theoretically affect cysteine metabolism and insulin signalling, which may be relevant for diabetic patients on tirzepatide, but this is uncommon at standard supplementation levels

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But as we age, and with increasing exposure to pollutants and stress, our natural glutathione levels decline

doi: 10.3390/ph17040489, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 149